Brain test 2 level 11 agent smith3/9/2024 ![]() ![]() Indeed, although microbes exhibit the ability to infiltrate the brain of cognitively healthy persons at various life stages, numerous reports indicate that the cerebral presence of microbial agents appears to be exacerbated as a consequence of AD-like pathological events, such as significant disruption of the blood–brain barrier (BBB), elevated neuroinflammation, and alarmingly, higher cerebral levels of amyloid-β (Aβ) peptide-the predominantly suspected driver of AD pathology. In recent decades, several studies done in human-derived samples and experimental models have connected pathogens and associated inflammatory pathways to AD pathology. ![]() At present, the specific causes leading to Alzheimer’s disease (AD) are still unidentified, although various co-morbidities and lifestyle patterns have been linked to disease incidence. ![]() More than a century ago, Aloysius Alzheimer proposed that microorganisms may be involved in the progression of dementia and associated pathological features such as the formation of senile plaques. ![]()
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